Score

Score is the total sum of points you've gained over a run. Your score is determined by 9 factors: highest combo, damage taken, fallen foes, rooms explored, loot collected, raids completed, relics collected, curses collected, and seconds spent.

Highest Combo adds 10 times the highest combo you achieved that run to your total score.

Damage Taken subtracts 10 points times the number of times you were hit over the course of your run from your total score (damage that doesn't decrease your combo still counts).

Fallen Foes adds 5 times the number of enemies you've defeated over the course of your run to your total score.

Rooms Explored adds 50 points times the number of rooms you've entered to your score.

Loot Collected adds one point per coin you've collected to your total score (money spent still counts towards your total Loot Collected score).

Raids Completed (missing)

Relics Collected adds 100 points per relic you collected that run to your total score.

Curses Collected adds 500 points per curse you collected that run to your total score.

Seconds Spent subtracts 1/2 of a point per second you spent on your run. (Unknown if slow-mo seconds extend the penalty and whether time spent navigating menus affects this penalty)